Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis

K Allott; SJ Schmidt; HP Yuen; SJ Wood; B Nelson; C Markulev; S Lavoie; WJ Brewer; MR Schäfer; N Mossaheb; M Schlögelhofer; S Smesny; IB Hickie; GE Berger; EYH Chen; L De Haan; DH Nieman; M Nordentoft; A Riecher-Rössler; S Verma; A Thompson; AR Yung; P Amminger; PD McGorry; J Hartmann

Journal article

Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis

K Allott, SJ Schmidt, HP Yuen, SJ Wood, B Nelson, C Markulev, S Lavoie, WJ Brewer, MR Schäfer, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, GE Berger, EYH Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler, S Verma Show all

Schizophrenia Bulletin Open | Published : 2022

DOI: 10.1093/schizbullopen/sgac008

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Abstract

Understanding longitudinal cognitive performance in individuals at ultra-high risk for psychosis (UHR) is important for informing theoretical models and treatment. A vital step in this endeavor is to determine whether there are UHR subgroups that have similar patterns of cognitive change over time. The aims were to: i) identify latent class trajectories of cognitive performance over 12-months in UHR individuals, ii) identify baseline demographic and clinical predictors of the resulting classes, and iii) determine whether trajectory classes were associated with transition to psychosis or functional outcomes. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS..

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University of Melbourne Researchers

Kelly Allott Author

Hok Yuen Author

Stephen Wood Author

Barnaby Nelson Author

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Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was supported by grant 07TGF-1102 from the Stanley Medical Research Institute, grant 566529 from the National Health and Medical Research Council (NHMRC) Australia (Drs McGorry, Hickie, and Yung, and Amminger), and a grant from the Colonial Foundation. Dr Allott was supported by a Career Development Fellowship from the NHMRC Australia (1141207) and a Dame Kate Campbell Fellowship from The University of Melbourne; Drs Amminger and Yung were supported by NHMRC Senior Research Fellowships 1080963 and 566593, respectively; Dr Nelson was supported by NHMRC Career Development Fellowship 1027532; and Dr McGorry was supported by Senior Principal Research Fellowship 1060996 from the NHMRC.